Ruthenium Based Anticancer Compounds and Their Importance

Natural Based Anticancer Drugs and Their Worthiness

Anticancer compounds derived from fungal endophytes: their importance and future challenges.

This is a review of anticancer agents isolated from endophytic fungi from 1990–2010. Endophytic fungi are defined as fungi that live asymptomatically within the tissues of higher plants. The designation ‘anticancer’ is based on the assessment of the authors of the paper of the cytotoxicity of each compound against specific cancer cell lines. Many of the compounds reported here were isolated exc...

natural based anticancer drugs and their worthiness

with the prevalence of every type of cancer increasing globally, the inability to treat and the severe side effects caused by chemotherapy and radiotherapy are some of the biggest problems facing cancer patients and their physicians.1many herbal medicines have replaced their chemical rivals; for example, emetine lost its ground to metronidazole as an amoebicidal agent, and digoxin has given its...

New ruthenium-based compounds with fewer and less severe side effects, could replace longstanding platinum-based anticancer drugs

Platinum therapies For half a century, the field of metalbased anticancer drugs has been dominated by the precious metal platinum. The discovery of platinum’s anticancer properties was made by chance during an experiment in 1965, conducted at Michigan State University by Barnett Rosenberg. Rosenberg used a platinum electrode to apply an electric field to a colony of E. coli, which was observed ...

Ligand substitutions between ruthenium–cymene compounds can control protein versus DNA targeting and anticancer activity

Ruthenium compounds have become promising alternatives to platinum drugs by displaying specific activities against different cancers and favourable toxicity and clearance properties. Nonetheless, their molecular targeting and mechanism of action are poorly understood. Here we study two prototypical ruthenium-arene agents-the cytotoxic antiprimary tumour compound [(η(6)-p-cymene)Ru(ethylene-diam...